http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-114958935-A
Outgoing Links
Predicate | Object |
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assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_8ee92593d3fc749b150d614077c226a5 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_f04e30a60ae408a7e9d832b566b387c1 |
classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C315-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12P13-04 |
classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12P13-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C315-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C317-24 |
filingDate | 2022-08-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_54d00b87b081bcfc9d3a925f5123f459 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6bbf3e15524698efd8bdf80cebcce048 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_569e7968ede0ea8b35ca0db89562bf44 |
publicationDate | 2022-08-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
publicationNumber | CN-114958935-A |
titleOfInvention | A kind of synthetic method of chiral (2S,3R)-p-methylsulfonyl phenylserine |
abstract | The invention discloses a method for synthesizing chiral (2S,3R)-p-methylsulfonyl phenylserine, belonging to the technical fields of chemical industry and pharmacy. The synthesis method comprises the following steps: an enzyme-catalyzed condensation reaction and an oxidation reaction; the The method for the enzymatic-catalyzed condensation reaction is as follows: adding 4-methylsulfoxide benzaldehyde, phosphate buffer, L-threonine, pyridoxal phosphate aqueous solution, and transaldolase into a reaction vessel, reacting in a water bath at 30° C., and reacting After 6-8h, a primary product is obtained; in the oxidation reaction, hydrogen peroxide is added to the primary product, the temperature is raised to 40° C., and a product solution is obtained after the reaction for 2 hours; in the oxidation reaction, hydrogen peroxide is added to the primary product, and the temperature is raised to 40° C. , after the reaction for 2h, a chiral (2S,3R)-p-methylsulfonylphenylserine solution is obtained; the present invention can improve the reaction conversion rate and the concentration of the target product, and reduce the post-processing cost of the reaction. |
isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-115947676-A |
priorityDate | 2022-08-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 522.