abstract |
The invention belongs to the technical field of biological immunity, and in particular relates to a monoclonal antibody against SARS-CoV-2 spike protein S2 and its application. The anti-SARS-CoV-2 spike protein S2 monoclonal antibody comprises VHCDR1, VHCDR2, VHCDR3 whose amino acid sequence is shown in SEQ ID NO: 1-3, and VLCDR1, VLCDR2 whose amino acid sequence is shown in SEQ ID NO: 4-6 , VLCDR3. The monoclonal antibody of the present invention can specifically recognize the 1202 ELGKYEQYIKWP 1213 sequence region on the SARS-CoV-2 spike protein, and has good specificity; the multiple sequence alignment analysis shows that the epitope is conserved, so the monoclonal antibody is in the It has good application prospects in the detection of SARS-CoV-2. |