http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-114957247-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_36753a15d2838b5d77ae40e8f9166011 |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y02P20-55 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D221-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D471-04 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D471-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D221-04 |
| filingDate | 2022-04-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_219c1c1ce14f7fa012c739c448b5229d http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ab708de8e5abfa31be5730b703cf1723 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_28cfff01d95c9d31ee890d53d31a1442 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_67d71253cac6bd41eb28c764c1513ffa |
| publicationDate | 2022-08-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-114957247-A |
| titleOfInvention | Synthetic method of Rimegepant and its intermediates |
| abstract | The present invention provides a kind of new synthetic method of Rimegepant intermediate, this method comprises the steps of synthesizing key intermediate 5 and chiral key intermediate 8, and the structure of these two intermediates is as follows: , The present invention also provides a method for preparing Rimegepant by utilizing the above-mentioned two intermediates, applying the technical scheme of the present invention, avoiding the use of compound a as a reaction raw material, reducing the cost, and the reductive amination step does not produce impurities; the synthetic chirality is the key The intermediate 8 avoids the use of sodium azide to improve the safety of the reaction; or avoids the use of titanium tetraisopropoxide and aluminum oxide, and the post-processing is simple, which is conducive to industrial scale-up production. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2023045608-A1 |
| priorityDate | 2022-04-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 137.