http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-114957163-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_42e307d314053c5f8cd97a01b065d725 |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y02P20-55 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D295-023 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D295-03 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D295-03 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D295-023 |
| filingDate | 2022-02-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9eba5ab043fdfb4a89e9e629fd16a92a http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_598bfecc7ac9c1507545489cf7ad72f1 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6752d8e587f7d0e7e88588ecd25f258e |
| publicationDate | 2022-08-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-114957163-A |
| titleOfInvention | A kind of preparation method of N-methyl homopiperazine |
| abstract | The invention relates to the technical field of medicinal chemistry and medicine, in particular to a preparation method of N-methyl homopiperazine. Using N-benzyl-4-piperidone as a starting material, react with hydroxylamine hydrochloride to prepare N-benzyl-4-piperidone oxime, and then undergo Beckmann rearrangement to prepare N-benzyl homopiperazine ‑5‑ketone, N‑benzyl homopiperazine‑5‑ketone is subjected to reduction reaction to obtain N‑benzyl homopiperazine, and N‑benzyl homopiperazine is then methylated to obtain 1‑benzyl‑4‑methyl Base-1,4-hompiperazine, 1-benzyl-4-methyl-1,4-homopiperazine are debenzylated to prepare N-methylhomopiperazine. The invention has mild reaction conditions, simple operation, simple post-treatment, little environmental pollution, high purity and good yield, and is suitable for industrial production. |
| priorityDate | 2022-02-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 158.