http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-114957115-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_d6ae8f85a597839e90ed1d76e19e272c |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D215-22 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D215-22 |
| filingDate | 2021-02-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f547fe425ae9db11946bdca93ccb11da http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f24972a29dfcac691356ad98ad7a7c10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ba7a7360800c7564829a9da13c7d2070 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_81faac458d2b095b2a7a8c41375169c6 |
| publicationDate | 2022-08-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-114957115-A |
| titleOfInvention | A kind of preparation method of aripiprazole monohydrate with low initial release degree |
| abstract | The invention relates to the technical field of pharmacy, and discloses a preparation method of aripiprazole monohydrate with low initial release degree. , stirred, filtered, and dried to obtain crude crystals; then added the crude crystals to mixed solvent B, stirred, and cooled for crystallization; finally filtered to obtain crystals, rinsed with cold mixed solvent C; dried to obtain aripipridine with low initial release azole monohydrate. The method of the invention can obtain high-purity, low-burst-release aripiprazole monohydrate bulk drug, wherein the proportion of anhydrous in the aripiprazole monohydrate crystal form is reduced from 20% to within 10%, and the scanning electron microscope observation The proportion of submicron-sized particles in the drug was significantly reduced, and the initial release rate (10min) in vitro was reduced from 36-46% to 12-30%. |
| priorityDate | 2021-02-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 28.