| abstract |
The invention discloses a continuous synthesis method of an acid chloride product. The method comprises the following steps: in a continuous flow reactor, under the action of an amide catalyst and/or pyridine, the organic acid and thionyl chloride are subjected to an acid chlorination reaction; the reaction temperature is 50-160 DEG C; the reaction pressure is 2- 15bar; the reaction time is 20～300s. The invention overcomes the defect of poor mass transfer and heat transfer performance of the kettle type reactor, the reaction can run smoothly, the reaction time is greatly shortened, the energy consumption is reduced, and the cost is saved; the operation is simple, the stability is high, high automation can be realized, and human interference is reduced. and errors, continuous production can be realized; the liquid holding volume in the reactor is small, which can effectively avoid the generation of hot spots in the exothermic reaction; the conversion rate is high, the selectivity is high, the side reactions are few, the crude product has no other impurities, and the yield is high , the post-processing is simple and easy to separate; the industrial amplification process has almost no amplification effect. |