| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_c2e7320205668c50c9af0fe81fa07347 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2750-14143
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2830-008 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-4716
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-86
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K48-0075
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K48-005 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K48-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-47 |
| filingDate |
2020-08-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b8aa23aba47a0905d16df189b2aab5d9
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_db41d6ae6ca5399ed4c52e48f0653bb6
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_eda9db9b27f9a2b6152f6aa9ca3cbce8 |
| publicationDate |
2022-08-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
CN-114945583-A |
| titleOfInvention |
Adeno-associated viral vector delivery of alpha-sarcoglycan and treatment of muscular dystrophy |
| abstract |
Described herein are methods of treating muscular dystrophy in a subject comprising using a systemic route of administration and administering the recombinant AAV vector AAVrh74.tMCK at a dose of from about 1.0×10 12 vg/kg to about 5.0×10 15 vg/kg .hSCGA. Also disclosed are methods of expressing an alpha-sarcoglycan gene in a cell or subject in need thereof, reducing serum CK levels, and increasing alpha-sarcoglycan-positive fibers in muscle tissue of the subject. |
| priorityDate |
2019-08-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |