| abstract |
Provided are isolated recombinant influenza viruses having PA, PB1, PB2, NP, NS, M, NA and HA viral segments, wherein the PB1 viral segments encode, and methods of making and using the same PB1 having a residue other than isoleucine at position 711 or the M virus segment encoding M1 having a residue other than methionine at position 128, wherein the recombinant influenza virus is relatively Enhanced replication in corresponding influenza viruses having a PB1 viral segment encoding PB1 with isoleucine at position 711 or an M viral region encoding M1 with methionine at position 128 part. |