http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-114921526-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_653c418e41edbb4e1ce8bc5e53e70cec |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2333-91011 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q1-682 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q1-6825 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-682 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-6825 |
| filingDate | 2022-06-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5f002612c4c0d7e7047817916d7c722d http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a616f0763ff34c4808bd0cffcce02a42 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4fe524e959a8a69c87a4d03abcbb6d19 |
| publicationDate | 2022-08-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-114921526-A |
| titleOfInvention | Methylation-driven construction of dual-color luminescent RNA nanosensors for label-free and ultrasensitive detection of multiple DNA methyltransferases |
| abstract | The invention belongs to the field of biological analysis, and provides a methylation-driven construction of a two-color luminescent RNA nano-sensor for label-free and ultra-sensitive detection of various DNA methyltransferases. Methylation-driven construction of a two-color luminescent RNA nanosensor enables label-free and ultrasensitive detection of a variety of DNA methyltransferases. Utilize the ultra-high specificity of MDREs for methylated DNA, efficient bicyclic cascade amplification, and high signal-to-noise ratio of luminescent RNA aptamer-fluorophore pairs. Compared with the reported DNA MTase assays, this nanosensor has distinct advantages: (1) ensure accurate quantification of low-abundance DNA MTases; (2) significantly improve the amplification efficiency; (3) achieve high signal-to-noise ratios Label-free and simultaneous detection of multiple DNA MTases; detection in a label-free manner, which is easy to operate and reduces costs. |
| priorityDate | 2022-06-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 58.