http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-114920670-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_33fd36030224734baffb461370dd3651 |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y02P20-584 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C303-22 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C303-38 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C303-38 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C311-39 |
| filingDate | 2022-07-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6549b90f9fbd6e3dddacc155da8e46fb http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_907af479a12acea48f328292abefef25 |
| publicationDate | 2022-08-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-114920670-A |
| titleOfInvention | A kind of preparation method of 5-chloro-2-aminobenzenesulfonamide |
| abstract | The invention discloses a preparation method of 5-chloro-2-aminobenzenesulfonamide, and relates to the technical field of organic compound preparation. A two-step reaction: the first step is to use 4-chloro-2-(chlorosulfonyl)benzoic acid and azide. Sodium nitrogen is the raw material, 4-chloro-2-(chlorosulfonyl) benzoic acid is added to the solvent, sodium azide is added to the system, sodium nitrite and sulfuric acid are added to the mixed solution after the reaction is incubated for a period of time, and after a period of ice bathing Sodium hydroxide is added to the mixed solution, washed with water and then added with an organic reagent for extraction, and the organic layer is recrystallized and purified after rotary evaporation to obtain the intermediate 2-amino-5-chlorobenzenesulfonyl chloride; the second step uses the intermediate 2-amino-5- Chlorobenzenesulfonyl chloride, the intermediate is added to water, and ammonia water is slowly added to the system; after the reaction, the filter cake is filtered, and the filter cake is extracted by the alcohol-water method to obtain an off-white powder, that is, the pure product of 5-chloro-2-aminobenzenesulfonamide. This method adopts simple equipment, no pressure operation, easy product purification, simple operation and good yield. |
| priorityDate | 2022-07-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 49.