http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-114887243-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_2f19a031ab4489e8e59f829d009f4afd |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61N2007-0034 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61N7-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61N7-00 |
| filingDate | 2022-05-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f59f7d105dad23acf27e76136c004dfb |
| publicationDate | 2022-08-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-114887243-A |
| titleOfInvention | Application of ultrasound in inducing hair follicle cells and hair growth |
| abstract | The invention discloses the application of ultrasonic waves in inducing hair follicle cells and hair growth, and is characterized in that, 30 kHz ultrasonic waves are used to inhibit the secretion levels of hair loss inducing factors DKK1 and TGF-β1 induced by dihydrotestosterone, and induce human dermal papilla cells hDPC and outer roots. Proliferative and anti-apoptotic effects of sheath keratinocytes for alopecia treatment. The present invention shows that ultrasound can significantly inhibit DKK1 and TGF-β1-induced apoptosis in human outer root sheath (ORS) keratinocytes, which is determined by cell viability assay, TUNEL assay and mRNA of apoptosis-related genes Bcl-2 and Bax expression level to determine. Furthermore, the results showed that direct treatment of human hair follicles with ultrasound accelerated hair growth, and protein expression of Ki-67, a proliferation marker of stromal cells, was also significantly increased in the hair follicles. Based on these results, we can conclude that ultrasound at 30 kHz is effective in treating hair loss, has the potential to treat hair loss, and can be used to develop new treatments for hair loss. |
| priorityDate | 2022-05-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 166.