| abstract |
The present invention relates to an immune adjuvant composition and a cancer vaccine based on the composition and application thereof. The immune adjuvant composition at least comprises a combination of (1) and (2) in the following components, (1) Poly(1) : C) or Poly (ICLC), (2) CpG-ODN, wherein, CpG-ODN is at least two of A-type CpG-ODN, B-type CpG-ODN and C-type CpG-ODN, and at least one of them It is B-type CpG-ODN or C-type CpG-ODN, (3) amino acid, polypeptide, lipid, carbohydrate, protein or inorganic salt. Based on the immune adjuvant composition, a cancer vaccine is provided, comprising nano-particles or micro-particles, the antigen component and the immune adjuvant composition loaded thereon. The immune adjuvant composition provided by the invention can fully exert the effect of enhancing the adjuvant to activate the cancer-specific T cell response, and better assist the vaccine to function. |