| abstract |
The present invention provides a class of tetrahydroisoquinoline derivatives as pan-KRAS inhibitors, specifically, the present invention provides a class of tetrahydroisoquinoline derivatives whose structural formula is shown in general formula (I), and pharmaceutically acceptable salts thereof, which have inhibitory activity against pan-KRAS. The present invention also provides a preparation method of such derivatives, their pharmaceutical compositions, salt-forming complexes, and their medical uses as pan-KRAS inhibitors in the treatment of different types of tumors. |