http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-114874156-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_7287e53817684738154aec255b3b63b3 |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07B2200-07 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y02P20-55 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12P17-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12P41-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D281-10 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D281-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12P41-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12P17-02 |
| filingDate | 2022-06-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c96c03b784cf17ab0e9495ebaa6b8d57 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8e4349b4cf3e8f4a844520be4ff15f4b http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0e8d9f3102cc2654f18596a65ef47fef http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0285bb4a484de74761701dc44c4c1fba http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ef7827416d37266efb03cb759206bfd8 |
| publicationDate | 2022-08-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-114874156-A |
| titleOfInvention | A kind of method for synthesizing diltiazem intermediate (2S)-cis-hydroxylactam |
| abstract | The invention relates to a method for synthesizing a diltiazem intermediate (2S)-cis-hydroxylactam. The synthesis method firstly uses p-methoxybenzaldehyde and methyl chloroacetate as reaction substrates to prepare a racemic epoxy ester intermediate , under the action of esterase, the intermediate of racemic epoxy ester is enzymatically resolved to obtain the intermediate of L-epoxy ester, and then the ring-opening addition is carried out between the intermediate of L-epoxy ester and o-aminothiophenol The ring-opening addition reaction product is obtained, and under the action of methanesulfonic acid, the ring-opening addition reaction product will undergo ring-closing condensation to obtain a crude product (2S)-cis-hydroxylactam, and finally refined with methanol to obtain a diltiazem intermediate (2S) ‑cis‑hydroxylactam pure product. The invention has simple synthetic route, high raw material utilization rate, low production cost, and is suitable for mass production, provides a new way for the synthesis of diltiazem intermediate (2S)-cis-hydroxylactam, and has strong industrial application prospects . |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-115521274-A |
| priorityDate | 2022-06-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 93.