| abstract |
The present invention provides a live poultry Salmonella enteritidis vaccine, comprising antigen and adjuvant, wherein the antigen is live Salmonella enterica (Salmonella enterica) R073ΔaroA strain, whose deposit number is CCTCC M 2022376. The Salmonella Enteritidis R073ΔaroA strain is prepared by deleting the aroA gene of the Salmonella Enteritidis R073 strain through the Red/ET homologous recombination system. The Salmonella Enteritidis vaccine provided by the present invention can be used by traditional methods, such as large-scale administration by economical and easy-to-operate spray and drinking water, or by intramuscular injection or other methods. |