| abstract |
The invention belongs to the field of biomedical polymer materials and medical instruments, and particularly relates to an injectable light-cured sodium alginate hydrogel and its application. The preparation method of the invention comprises the steps of using glycidyl methacrylate to open the ring and graft to the polymer segment of the sodium alginate, and to introduce a double bond group to obtain a photocurable modified sodium alginate polymer. By introducing lithium magnesium silicate, the released magnesium ions are cross-linked with the modified sodium alginate polymer to form a pregel, which can be injected at the wound site and highly conforms to the shape of the wound; and under UV light irradiation, free radical polymerization is induced In situ gelation forms a second-layer hydrogel network, which further enhances the mechanical properties of the hydrogel network. By adjusting the solid content of the polymer and the concentration of lithium magnesium silicate, the mechanical properties of the tissue engineering scaffold, such as swelling degradation performance and compression resistance, can be significantly regulated. The sodium alginate hydrogel of the invention is easy to operate, cheap and easy to obtain, has the characteristics of mild reaction conditions, strong stability, good mechanical properties and excellent biocompatibility, etc., and can be widely used in medical dressings, 3D printing and tissue engineering. |