http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-114853822-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_85876b4a8c2dfc0472b766e1e31047d9 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_540a6caa249680752d9e526d06087800 |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y02P20-55 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C40B40-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07H21-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07H21-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07H1-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07H21-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07H1-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C40B40-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07H21-04 |
| filingDate | 2022-06-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_116c92fd6a8fd491084d4e8b0cbf7628 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7e47c43a9b3347ca926dabdfa87ce126 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2f6c087f2ac6d5485e57f5cf10c3696f http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_301932bc86c24eba842437a8e9c2b576 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2aebb6b055b6de6ba0350613d4ca03ee |
| publicationDate | 2022-08-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-114853822-A |
| titleOfInvention | A kind of oligonucleotide-disulfide and its synthesis method |
| abstract | The invention provides an oligonucleotide-disulfide and a synthesis method thereof, belonging to the field of gene coding compound library construction. The oligonucleotide-disulfide of the present invention is shown in formula I. The synthesis method of the oligonucleotide-disulfide of the present invention is that under alkaline conditions, the oligonucleotide-thiol compound 1 and the thiol compound 2 are reacted in a solvent to obtain the oligonucleotide shown in formula I Acid-disulfide. The method for synthesizing oligonucleotide-disulfide of the present invention has good universality and simple operation, and can synthesize disulfide on oligonucleotide with high efficiency. At the same time, the method of the present invention has little damage to DNA and good DNA integrity during the reaction. The invention enriches the chemical reaction types for synthesizing the coded compound library on DNA, constructs a new disulfide skeleton for synthesizing the DNA coded compound library, and provides a fast, practical and effective way for synthesizing diverse disulfides. It has a very good application prospect in drug development. |
| priorityDate | 2022-06-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 270.