| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_d7222d0723a19519b6b0e5296ba3d8eb |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y02P20-55 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D233-64 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D233-64 |
| filingDate |
2022-04-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e5c63c4dc5854f60d3f6180050549784
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b172cc990173d1b2b09a4f05694c08c3
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f064e7ed9180a2c474c150c67821ff70
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ebf1db7b5e916f75ce57aace1f08e97f
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_67dd35eaca83b23e2d519c83f2c702de
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_13da337dbf21853d8f494d78658f3a38
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_35262f19c3bf34d0cc6c5787b2583cf2
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c9619f9a057f672e02513cc7d5f9f125
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f5c6aca55cd83a29cafe7d3980a9e815
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7b548bb67e653cc16c3cf616b096a758 |
| publicationDate |
2022-08-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
CN-114853677-A |
| titleOfInvention |
Preparation method of leucyl histidine |
| abstract |
The invention discloses a preparation method of leucyl histidine, which belongs to the technical field of organic synthesis. The method is to use phthalic anhydride to protect leucine to obtain phthaloyl-L-leucine, and then use thionyl chloride to perform acid chloride on it to obtain phthaloyl-L-leucine chloride; Methyldisilazane protects histidine to obtain TMS-histidine; condenses phthaloyl-L-leucyl chloride and TMS-histidine to obtain protected leucyl-histidine; deprotection And purified to obtain the target leucyl histidine. Compared with solid-phase synthesis, liquid-phase synthesis has lower cost and less pollution. The whole production process is simple and suitable for industrial production. |
| priorityDate |
2022-04-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |