http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-114848633-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_febe359da5840e2e95428edf1443fedf |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y02A50-30 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P39-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-397 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P1-16 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P39-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-397 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P1-16 |
| filingDate | 2022-04-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c27d9a6c7d2cb44cc4eb13a12abcc773 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_befc3b727b72a9c24d4a5493a227dc35 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_88397be432befea72dd5b87b8e9b041b http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_91d4165b919702b81be2c48294f7622a http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b5fb6421022578030da5a11b9b4b1863 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b41e77e79d7e37f207e4554450f20137 |
| publicationDate | 2022-08-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-114848633-A |
| titleOfInvention | A kind of medicine for treating α-amanita poisoning and application thereof |
| abstract | The invention provides a medicine for treating α-amanita poisoning and application thereof. Because α-amanita toxin can enter hepatocytes through the NA + -taurocholic acid co-transporter, and exert a toxic effect. The invention discloses that for inhibiting the NA+-taurocholic acid co-transporter on the basement membrane of hepatocytes, it can block the repeated entry of α-amanita toxin into hepatocytes and enterohepatic circulation with bile, and prevent the α-amanita toxin from interacting with the liver. Combined with RNA polymerase II, it increases the level of transcription, maintains the normal translation process, and enables hepatocytes to synthesize the necessary proteins, thereby exerting a protective effect on the liver. The use of NTCP inhibitors provides new ideas and directions for the treatment of α-amanita toxin liver injury. In particular, the present invention has important value when there is no clear molecular mechanism and specific drug for α-amanita poisoning. |
| priorityDate | 2022-04-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 88.