| abstract |
The invention discloses a compound preparation of empagliflozin and metformin hydrochloride and a preparation method thereof. The compound preparation comprises empagliflozin granules and metformin hydrochloride granules; the empagliflozin granules include empagliflozin, polacrilin potassium , maltose-cyclodextrin, disintegrant, and binder; metformin hydrochloride granules include metformin hydrochloride, diluent, disintegrant, and binder; wherein the particle size of empagliflozin d0.9 is not greater than 30 μm. The compound preparation of the invention can solve the problem that the dosage of empagliflozin and metformin hydrochloride is very different and it is difficult to control the content uniformity; at the same time, it can effectively overcome the problem of poor solubility of empagliflozin, and realize the dissolution curve of empagliflozin and metformin hydrochloride and the original research. The same effect as the listed products. |