| abstract |
The invention discloses a biological marker for the syndrome of hyperthermia, which is intervened by Huanglian Jiedu Pill, and an application thereof, and relates to the field of biological medicine. The biomarker is that the marker is TNF-α, IL-8, IL-10, 4-HNE, succinic acid, pantothenic acid or hypoxanthine. The present invention confirms that Huanglian Jiedu Pill can significantly regulate TNF-α, IL-8, 4-HNE and succinic acid through a small sample size verification study. Through a phase II clinical randomized, double-blind, multi-center, placebo-controlled large-sample exploration and screening study, it was found that IL-10 in saliva, 4-HNE in plasma and pantothenic acid and hypoxanthine in urine can become Huanglian Jiedu Pills The efficacy or pathogenesis of pathogenic evolution of real heat and fire poison syndrome. |