| abstract |
The invention discloses a preparation method, product and application of regenerated silk fibroin/ε-polylysine composite hydrogel. The composite hydrogel is made of high-concentration regenerated silk fibroin and ε-polylysine fully mixed , and then EDC/NHS is used as a cross-linking agent to fully mix and cross-link to obtain a regenerated silk fibroin/ε-polylysine composite hydrogel; the present invention uses ε-polylysine to mix with the regenerated silk fibroin, for The cross-linking of EDC provides more reactive groups to solve the problem of the lack of cross-linking sites for regenerated silk fibroin. The obtained composite hydrogel is colorless and transparent, has a three-dimensional network structure, and has increased shear strain. Good biodegradability, high degree of swelling, and no adverse stimulation to macrophages, theoretically will not cause the inflammatory response to aggravate in the inflammatory response of wound repair, which is conducive to the normal progress of wound repair, so it can be used as a wound. Repair dressings are used. |