| abstract |
The invention belongs to the technical field of biomedicine, and in particular relates to a viologen molecule with reduction response performance, a polypeptide-viologen derivative, a preparation method and an application. The viologen molecular structure is C n V 2+ Mal, where n=1, 3, 5; V 2+ represents ionic viologen molecule, Mal represents maleimide; the polypeptide molecules Pep, C n V 2+ Mal was dissolved in deionized water, dissolved and mixed, and the solution after the reaction at room temperature was placed in a dialysis bag with a molecular weight cut-off of 3500 for dialysis for more than 24 hours, and the polypeptide-viologen derivative was obtained after drying the solution in the dialysis bag. The invention utilizes the charged property of the polypeptide to achieve selective adsorption on the surface of tumor cells, and utilizes the hydrophobicity of viologen molecules under the action of a reducing agent to achieve a destructive effect on cell membranes, thereby leading to the death of tumor cells and realizing anti-tumor potential. Therefore, the viologen molecules and polypeptide-viologen derivatives provided by the present invention have good application prospects in antibacterial and antitumor aspects. |