| abstract |
The invention relates to the technical field of biopharmaceuticals, in particular to the field of organic synthesis, and more particularly to a preparation process of 1-mercaptomethylcyclopropylacetic acid. In the process, the raw material 1-hydroxymethylcyclopropylacetonitrile is subjected to sulfonylation reaction under the action of substituted-sulfonyl chloride, and then thiourea is subjected to sulfhydrylation reaction, and finally alkali is added to obtain the target product 1-mercaptomethyl ring Propyl acetic acid. The preparation method of the invention has the advantages of low cost, simple operation and short process route, and can meet actual production needs. |