http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-114805631-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_fea641961ea08c9adc7f9f8578e5acae |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C08B37-0072 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61Q19-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K8-735 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61Q19-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K8-73 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C08B37-08 |
| filingDate | 2022-03-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b359f8b89809305228f872fa2626af21 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e53ab90ee10fe88f72dfccb2c9db4fe1 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2449b98c05f442da0dfe91ebf432df18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b8922c1462ace1d82694a8604325298a |
| publicationDate | 2022-07-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-114805631-A |
| titleOfInvention | Highly active hyaluronic acid-polypeptide conjugate and its preparation method and application |
| abstract | The present invention discloses a highly active hyaluronic acid-polypeptide conjugate and its preparation method and application. Wherein, the preparation method of the highly active hyaluronic acid-polypeptide conjugate is: preparing aldehyde-modified hyaluronic acid; dissolving the aldehyde-modified hyaluronic acid in a buffer solution, adding auxin and sodium cyanoborohydride, and reacting ; Add ethyl carbazate to carry out the reaction; finally obtain a hyaluronic acid-polypeptide conjugate; the technical scheme of the present invention can perfectly connect auxin to hyaluronic acid, and the binding rate is about 70%; The secondary structure of the auxin in the hyaluronic acid-polypeptide conjugate did not change; and in the skin tissue test, the hyaluronic acid-polypeptide conjugate could effectively deliver to the dermis. |
| priorityDate | 2022-03-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 40.