| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_2144b5ff78f3e7af583517fffe0d5feb |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-00 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K7-08
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-02 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K1-14
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P25-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P25-02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-10
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K1-06
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K1-04
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K1-107
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K7-08
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K1-36 |
| filingDate |
2022-03-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_af84c3cce5ab0cfbb08d18006ea4d82b
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_035f1c02b8ea23d67532fa43e1024331 |
| publicationDate |
2022-07-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
CN-114805491-A |
| titleOfInvention |
A kind of conotoxin KIIIA mutant and its preparation method and application |
| abstract |
The present invention provides a conotoxin KIIIA mutant whose amino acid sequence is SEQ ID NO: 1: Xaa1CXaa2CXaa3Xaa4KWCXaa5DHXaa6RXaa7C*. The present invention also provides a preparation method and application of the conotoxin KIIIA mutant. The invention realizes the rational design of two pairs of disulfide bond analogs of conotoxin targeting Nav1.7 channel, greatly improves the synthesis efficiency of conotoxin, and reduces the synthesis cost. |
| priorityDate |
2022-03-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |