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filingDate 2022-05-05-04:00^^<http://www.w3.org/2001/XMLSchema#date>
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publicationDate 2022-07-29-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber CN-114805262-A
titleOfInvention A viscosity- and polarity-responsive platform fluorescent probe, a hydrogen sulfide detection fluorescent probe, and its synthesis process and application
abstract The invention discloses a viscosity- and polarity-responsive platform fluorescent probe, a hydrogen sulfide detection fluorescent probe, and a synthesis process and application thereof. The structure of the hydrogen sulfide detection fluorescent probe is shown below; . Aiming at the problems of poor operability and low sensitivity in the detection of polarity and viscosity in the physiological microenvironment, the invention provides a high-sensitivity platform fluorescent probe that can be used for detection of environmental viscosity and polarity. The change of environmental viscosity is reflected by the violent change of fluorescence intensity, and the change of environmental polarity is reflected by the change of fluorescence emission position; at the same time, the probe molecule can serve as an excellent platform molecule for the synthesis of probes in different application fields; The hydroxyl group of the fluorescent probe molecule is used to obtain a high-sensitivity hydrogen sulfide detection fluorescent probe with a detection sensitivity of up to 36 nanomolar, which can be used for monitoring hydrogen sulfide in cells.
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