http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-114805100-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_061db74eb6df18ea4b490cd996406ae0 |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C2601-14 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C221-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P13-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C45-455 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C49-252 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C225-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C221-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P13-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C45-45 |
| filingDate | 2022-04-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3c780b66406fd55759b8567ed93c604c http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a40d7d87d12bf4428468ca1ef9b87ba7 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1111b563b03fe477ac474a65cc8fb24e |
| publicationDate | 2022-07-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-114805100-A |
| titleOfInvention | A kind of preparation method of oxybutynin hydrochloride |
| abstract | The invention discloses a preparation method of oxybutynin hydrochloride (chemical name: α-cyclohexyl-α-hydroxy-phenylacetic acid-4-diethylamino-2-butynyl ester hydrochloride), comprising the following steps: α-Cyclohexyl-α-Hydroxyphenylacetic acid and 3-chloropropyne are esterified with 3-chloropropyne under a suitable solvent and basic catalyst to generate an intermediate: α-Cyclohexyl-α-Hydroxyphenylacetic acid Propargyl ester, then Mannich reaction with 36% formaldehyde solution and diethylamine to generate oxybutynin, and finally salify with hydrochloric acid to generate oxybutynin hydrochloride. The reaction routes of the invention are relatively simple, do not involve reactions under harsh chemical reaction conditions, do not involve high-risk chemical reaction processes, and are suitable for industrial production. |
| priorityDate | 2022-04-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 73.