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filingDate 2021-01-28-04:00^^<http://www.w3.org/2001/XMLSchema#date>
inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f3b1f66079de847708fa290f86ea2958
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publicationDate 2022-07-29-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber CN-114796607-A
titleOfInvention Biomaterials, preforms filled with collagen nanofibers and their preparation and application
abstract The present application discloses a biomaterial pre-product and biomaterial filled with collagen nanofibers. The biomaterial includes a biomatrix and collagen filled in the biomatrix and cross-linked. After the biomaterial is folded, it absorbs water again without obvious crease; The present application also discloses a biomaterial pre-product and a method for preparing the biomaterial. The biomaterial is exposed to a collagen-containing solution for pretreatment. The collagen is first dispersed in the biomaterial and then self-assembled into nano-collagen fibers. The product; the preform is exposed to the cross-linking agent, and the biological material is obtained by cross-linking. The present application also discloses a heart valve and interventional system based on biomaterials. The present application solves the problem of recovery after compression of the dehydrated biological valve by filling collagen and realizing its self-assembly into a nanofiber structure in the biological valve, which is further fixed by cross-linking with glutaraldehyde, while avoiding the introduction of a large number of new materials, reducing the Immunogenicity of biological valves.
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type http://data.epo.org/linked-data/def/patent/Publication

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