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filingDate 2022-05-30-04:00^^<http://www.w3.org/2001/XMLSchema#date>
grantDate 2022-11-29-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationDate 2022-11-29-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber CN-114796603-B
titleOfInvention A kind of conductive hydrogel based on chitosan/xanthan gum interpenetrating network and preparation method thereof
abstract The invention provides a conductive hydrogel based on a chitosan/xanthan gum interpenetrating network and a preparation method thereof, belonging to the technical field of natural biopolymer materials. The acidic substance GDL is used to dissolve CS, and the ‑NH 2 of CS is protonated during the preparation process, combined with the ‑COOH of XG and PEDOT‑HA in the system, and a conductive hydrogel with stable structure can be formed after cross-linking. Drying technique to prepare dry scaffolds. In the present invention, GDL is a green acidic substance, which has the characteristics of step-by-step ionization and slow pH change. The preparation process does not need to add other chemical cross-linking agents, so that the preparation process is simple. The conductive hydrogel scaffold prepared by the present invention has good water absorption, high porosity, suitable electrical conductivity and mechanical properties; by simulating the micro-electrical environment in which nerve cells live in vitro, nerve tissue repair is completed; the SEM photos of the cells on the scaffold show that the scaffold It contains a large number of cells, and the cells are in a staggered network structure. It can be seen that the prepared conductive hydrogel scaffold has the potential to be applied to neural tissue engineering.
priorityDate 2022-05-30-04:00^^<http://www.w3.org/2001/XMLSchema#date>
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