http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-114796498-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_08dde60e3e0ca1e6ffaa5143e5c8477a |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K45-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K45-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-7088 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-7088 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K45-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K45-06 |
| filingDate | 2022-01-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6bfb5d89810b00fbbe87954e50871443 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_954a44965d4abd5978ff77e0dca7bfd8 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b3c854150899da8058ceaceb8f7c7ab7 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4f5fea065ffa2271d8b012e4aadb5e7d |
| publicationDate | 2022-07-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-114796498-A |
| titleOfInvention | Application of substances inhibiting MUC1 glycosylation modification in improving the sensitivity of breast cancer cells to anti-breast cancer drugs |
| abstract | The invention discloses the application of a substance inhibiting MUCl glycosylation modification in improving the sensitivity of breast cancer cells to anti-breast cancer drugs. The present invention proves through cell experiments that the sensitivity of flavonoids such as apigenin, chrysin, geranin, luteolin and quercetin and clinical small molecule drugs (such as cisplatin, 5-fluorouracil, bleomycin) All depend on the expression of MUC1 or the glycosylation modification of MUC1; animal experiments have shown that knocking out MUC1 can effectively improve drug sensitivity, promote drug toxicity in vivo, and reduce tumor development, so as to achieve the purpose of treating breast cancer. The invention has important application value. |
| priorityDate | 2022-01-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 380.