http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-114796480-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_2711ddefa9b50969da314d7bd318cdba http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_72206ca96c18ac1fe3f5b21bb02a5bb1 |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K2039-55505 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K2039-55583 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K2039-57 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K39-39 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K39-39 |
| filingDate | 2022-06-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_14171f073aaca3e4189580fc01578e18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c0cd2b5bdee155416a34c42db61d11f7 |
| publicationDate | 2022-07-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-114796480-A |
| titleOfInvention | A kind of preparation method of composite nanoparticle aluminum adjuvant |
| abstract | A preparation method of a composite nanoparticle aluminum adjuvant relates to the technical field of vaccine adjuvants, in particular to a preparation method of a nanocomposite vaccine adjuvant. The purpose is to solve the problem that the existing aluminum salt adjuvant lacks the ability to induce Th1-type immune response and cannot induce mucosal immune response. Methods: 1. Configure soluble aluminum salt solution. 2. Preparation of N-2-hydroxypropyltrimethylammonium chloride chitosan with controllable substitution degree. 3. Dissolving the N-2-HACC prepared in step 2 in the sodium acetate buffer solution, and stirring to obtain the N-2-HACC solution; 4. adding the anionic polymer solution to the N-2-HACC solution, stirring evenly to obtain mixture. 5. Preparation of N-2-HACC-Al composite nanoparticle aluminum adjuvant. The method can improve the yield under the premise of controlling the particle size, so that the yield is greatly increased. Positively charged and stable nanoparticles show good delivery and immune enhancement. The present invention is used for preparing aluminum adjuvant for vaccine. |
| priorityDate | 2022-06-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 70.