| abstract |
The present invention relates to a sofosbuvir pharmaceutical composition, its preparation method and its application. One of the objects of the present invention is to provide a preparation method of a pharmaceutical composition of sofosbuvir or its derivatives, comprising the following steps: (1) mixing sofosbuvir or its derivatives with a pharmaceutically acceptable carrier, The premix is obtained, and then the premix is dry granulated for the second time to obtain the intragranular part, wherein the pharmaceutically acceptable carrier is selected from the group consisting of diluents, disintegrants, glidants, and lubricants. any one or a combination thereof; (2) mixing the intragranular part obtained in step (1) with an extragranular pharmaceutically acceptable carrier to obtain a total mixture, tableting, and coating, wherein, the The pharmaceutically acceptable carrier is selected from any one of diluents, disintegrants, glidants, lubricants or a combination thereof. The preparation method of the pharmaceutical composition of sofosbuvir or its derivatives of the present invention improves the bulk density and fluidity of the granulated particles, and the quality of the obtained product is controllable. |