| abstract |
The invention discloses a method for constructing an animal model of pemphigus vulgaris. By using the vaccination technology, desmosome mucin 3 is used as the vaccine antigen to immunize wild-type mice for the first time/boost immunization. The phenotypes began to appear on the 35th day, including the overall phenotype of mice with blisters on the hind feet and tail, epidermal exfoliation, and skin ulceration; serum autoantibodies; histological examination of epidermal acantholysis, antibody deposition and other pemphigus vulgaris-like Some mice developed local skin depilation, ulceration, keratoconjunctivitis and other disease phenotypes, mimicking the clinical symptoms of pemphigus vulgaris and providing an important tool for immunotherapy of pemphigus vulgaris. |