http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-114790201-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_e70ecf57c4f9f4ab0240aabe84dd2f76 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D407-04 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D407-04 |
| filingDate | 2022-05-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_354813ac1849cde017e483d5a57139f6 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0e108339a19a1a9bc4141edd13b405a1 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_160a7930e698958f6a0478fe6763481c http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1747525917ec3dbb8f0400d931795811 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_74399bc856c46bf7f1855d99ab1ccd64 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8edfda6943a778502b756140c0d9971d http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d8f58f3a1cd9bc345eb1e8eefb2f3fa4 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e3431c3e6eb42fddc0a715a5197d75bd http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6a521b8393fecdbb3ff49e32f8fd7d2a |
| publicationDate | 2022-07-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-114790201-A |
| titleOfInvention | A kind of vitexin derivative and its preparation method and application |
| abstract | The invention relates to the technical field of antitumor drugs, and provides a vitexin derivative and a preparation method and application thereof. In the present invention, the structure of vitexin is chemically modified, and the 7, 4' or 5, 7, 4' positions of the vitexin are substituted, and the obtained vitexin derivatives have high anti-tumor activity and have broad application in preparing anti-tumor drugs. prospect. The results of the examples show that the unreported vitexin derivatives L1-L11 provided by the present invention have significantly stronger inhibitory effects on human lung cancer cell A549 than vitexin itself, and L3, L4, L6, L7, L8, and L9 are significantly stronger than vitexin itself. The inhibitory effect of human colon cancer cell HCT116 was stronger than that of cisplatin, and the inhibitory effect of L3, L6 and L8 on human hepatoma cells was stronger than that of cisplatin. The present invention also provides a preparation method of the vitexin derivative described in the above scheme. The preparation method provided by the present invention has simple steps and is easy to operate. |
| priorityDate | 2022-05-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
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