http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-114790139-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_885ac25d87fdcf28e2c70b8962fd0beb |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C253-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C51-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C51-15 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C17-093 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C51-15 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C51-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C63-70 |
| filingDate | 2021-01-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_04997e8e3b7be36a8ac4480840de0b43 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6e409addd94eefd1dcd855f094ab483b http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5c3774e56a80f744de070db23dbf746d http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_737eac6c78807eb93a3f14079175a659 |
| publicationDate | 2022-07-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-114790139-A |
| titleOfInvention | A method for synthesizing 2-chloro-4-fluorobenzoic acid with 2-chloro-4-aminobromobenzene as raw material |
| abstract | The invention relates to the field of organic synthesis, in particular to a method for synthesizing 2-chloro-4-fluorobenzoic acid using 2-chloro-4-aminobromobenzene as a raw material, which is characterized in that it comprises the following steps: 2-chloro-4-amino 2-chloro-4-fluorobromobenzene is produced by diazotization of bromobenzene; 2-chloro-4-fluorobromobenzene is reacted with magnesium to produce Grignard reagent and then reacted with carbon dioxide to produce 2-chloro-4-fluorobenzoic acid; or 2-chloro-4-fluorobromobenzene reacts with cuprous cyanide to generate 2-chloro-4-fluorobenzonitrile; 2-chloro-4-fluorobenzonitrile is hydrolyzed under acidic conditions to generate 2-chloro-4-fluorobenzoic acid , or hydrolyzed under alkaline conditions to generate 2-chloro-4-fluorobenzoate, and 2-chloro-4-fluorobenzoate is acidified to obtain 2-chloro-4-fluorobenzoic acid. The method for synthesizing 2-chloro-4-fluorobenzoic acid using 2-chloro-4-aminobenzonitrile as a raw material provided by the invention avoids the use of expensive precious metal catalysts and highly toxic reagents, and the used reagents are environmentally friendly and reduce costs , the process is simplified, the yield is high, the deficiencies of the prior art are overcome, and it is suitable for large-scale industrial production. |
| priorityDate | 2021-01-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 95.