http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-114752688-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_03f4b2c1fd53051d06996fe5718e6838 |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q2600-158 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K35-28 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q1-6888 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P19-08 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-6888 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K35-28 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P19-08 |
| filingDate | 2022-04-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d2733670054642cc20fda62a6717d0e6 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_09c025d163096fd18160594c0b47b4d0 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_38f806f847e0036ffe3057d4fbf69c65 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_969cac90c3bb9500475eda12ac24e8cb http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_eaedb1aee9877c11d25951d5d0ca459b |
| publicationDate | 2022-07-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-114752688-A |
| titleOfInvention | Methods, probes and kits for identifying human embryonic bone marrow-derived mesenchymal stem cells and their uses |
| abstract | The present invention relates to a method for identifying and screening human embryonic bone marrow-derived mesenchymal stem cells, a combination of related detection agents, a kit and related applications. The present invention comprehensively screened human embryonic BM nucleated cells (BMNCs) at single-cell resolution, using two complementary strategies (STRT and 10X genomics) for scRNA‑seq analysis, identified LIFR + PDGFRB + as MSCs specific markers. The present invention also finds that LIFR + PDGFRB + CD45 - CD31 - CD235a - MSC can effectively rebuild the hematopoietic microenvironment in vivo. The present invention also identifies a subset of unipotent osteoprogenitor cells expressing TM4SF1 + CD44 + CD73 + CD45 - CD31 - CD235a-, which have osteogenic potential. Therefore, the present invention identifies two types of human embryonic bone marrow MSCs, and the present invention will deepen the understanding of human embryonic bone marrow-derived MSCs and further promote the understanding of the clinical application of MSCs. |
| priorityDate | 2022-04-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 294.