| abstract |
The invention relates to the field of medical materials, in particular to a coating material and a preparation method and application thereof. The preparation method of the coating material comprises the following steps: 1) placing a base material formed with an amino protective layer on a bifunctional modification In the polyethylene glycol solution of 1, the base material is grafted with bifunctional modified polyethylene glycol; 2) The product obtained in step 1) is placed in the primary amine compound solution, and the primary amine compound is coupled to the step 1) on the product obtained; 3) the product obtained in step 2) is placed in an MPC solution, and MPC is grafted on the product obtained in step 2) through Michael addition reaction, that is, the coating material is obtained. The coating material obtained by the preparation method can be used in the surface modification of medical devices. The coating material has excellent lubricity, anticoagulant properties and fastness. |