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filingDate 2022-03-18-04:00^^<http://www.w3.org/2001/XMLSchema#date>
inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0112620dc4eb566db67ce6ab2b3d0800
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publicationDate 2022-07-15-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber CN-114748695-A
titleOfInvention Method for improving anti-calcification and anti-coagulation properties of biological valve material by post-crosslinking of double bonds
abstract The present application discloses a method for improving the anti-calcification and anti-coagulation properties of a biological valve material by double bond post-crosslinking. (1) The biological material is immersed in a solution containing a first functional monomer for physical infiltration; the first functional monomer has At least one amino group and at least one carbon-carbon double bond; (2) adding an aldehyde-based crosslinking agent to the system in step (1) to perform co-crosslinking; (3) soaking the biological material treated in step (2) in Physical infiltration is carried out in the solution containing the second functional monomer; the second functional monomer has at least one carbon-carbon double bond and at least one functional group B; (4) adding an initiator to the system in step (3) to initiate Double bond aggregation. The method of the present application forms more and larger polymer cross-linked networks through double cross-linking, improves the cross-linking degree of the biomaterial and improves the anti-calcification performance; additional functional groups are also introduced while the carbon-carbon double bond is introduced twice. Clusters can endow biomaterials with new properties and further improve the properties of biomaterials.
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priorityDate 2021-11-17-04:00^^<http://www.w3.org/2001/XMLSchema#date>
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