http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-114748422-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_f7db9565eff81c4dba42c5633ccb4feb |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y02A50-30 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-549 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-366 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-1075 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-6923 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-54 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-69 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K9-107 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-366 |
| filingDate | 2022-05-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_07c2b6f299ce40853cc6cbe018acc155 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3d1d89144e50b56d655068a41768b987 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_00f0f66e19f0c1994d4106b35ad83ea1 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f63c8a5fee9382da3e3c3059e73dcdf2 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6af7e94d1464a79a2588a547152a2d10 |
| publicationDate | 2022-07-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-114748422-A |
| titleOfInvention | A kind of preparation method of dihydroartemisinin self-assembled nano-oral emulsion |
| abstract | A preparation method of dihydroartemisinin self-assembled nanometer oral emulsion comprises the steps of preparation of dihydroartemisinin self-assembled nanoparticles, preparation of loaded matrix, dispersion, homogenization, canning and the like; The maximum particle size of hydroartemisinin nanoparticles is about 103.52 nm, with normal distribution, uniform and regular morphology, good dispersibility, and no agglomeration. The self-assembled dihydroartemisinin nanoparticles have a drug loading of up to 90.1%. Correspondingly released under conditions; the oral emulsion prepared by the invention has good stability, and has no oil-water layer and agglomeration under extreme conditions such as high temperature for 24 months, high humidity for 24 months, and centrifugation for 30 minutes, the content is stable and does not decrease, and the product stability is good. , long shelf life. The self-assembled dihydroartemisinin nanoparticle oral emulsion of the present invention can significantly improve the bioavailability of dihydroartemisinin, increase the targeted accumulation of dihydroartemisinin in tumors, and significantly improve the resistance of dihydroartemisinin. tumor effect. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-116173009-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-116173009-B |
| priorityDate | 2022-05-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 47.