| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_692cbb3851ecc84f91ea384071aedd14 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01K2227-105
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01K2217-072
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01K2207-15
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01K2267-0368
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2310-20
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2800-107 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K49-0008
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01K67-0278
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-113
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-8509
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-89
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-47 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-12
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-113
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K49-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A01K67-027
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-85
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-89 |
| filingDate |
2022-04-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_27a5e82c5a6633412bb5ff33328c0997
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3b8da6fcc965129afdad207740adb55a
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ac0939ba51861e970ba7f83e964f6046
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1fe0b8fad61584aaab107abe1a33debc |
| publicationDate |
2022-07-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
CN-114747541-A |
| titleOfInvention |
Construction method and application of a PSGL-1 humanized non-human animal model |
| abstract |
The invention discloses a construction method and application of a PSGL-1 humanized non-human animal model. The invention utilizes CRISPR/Cas9 technology to knock in the human PSGL-1 gene at the Rosa26loci site of the non-human animal, and constructs a non-human animal model capable of expressing the human PSGL-1. Through relevant experiments, it is shown that the present invention has successfully constructed a humanized PSGL-1 non-human animal model at the nucleic acid level and the protein level respectively. The non-human animal model can be used to study the role of human PSGL-1 protein in the pathogenesis of inflammation-related diseases, and to evaluate the safety and efficacy of humanized PSGL-1 antibody drugs. |
| priorityDate |
2022-04-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |