| abstract |
The invention also discloses a copper nanoparticle-clove oil double-layer antibacterial hydrogel and a preparation method thereof. The hydrogel is a double-layer hydrogel, and the double-layer hydrogel is characterized in terms of morphology, structure, property and performance Great improvement. Compared with the single-layer CuNPs/PVA and Oil/PVA/PEG hydrogels, the overall bacteriostatic and mechanical properties of the bilayer CuNPs‑Oil/PVA/PEG hydrogels were significantly improved. The prepared bilayer CuNPs‑Oil/PVA/PEG hydrogel, the upper layer with strong antibacterial ability is in direct contact with the skin, which can solve the problems of cytotoxicity and bioincompatibility. The lower layer is used to promote the growth of epithelial tissue, absorb wound exudate, has excellent biocompatibility, and promote wound healing while inhibiting bacteriostatic growth. The anti-oxidative clove oil in the upper layer penetrates into the lower layer, which can alleviate the oxidation of CuNPs and improve the antibacterial and stability of the lower layer of the hydrogel. |