| abstract |
The invention belongs to the technical field of biomedical materials, and particularly relates to a preparation method and application of a wet adhesive hydrogel for dura damage repair. The hydrogel material includes acrylic acid, methyl acrylate, acrylamide, a crosslinking agent and a photoinitiator (which may also include N-succinimidyl acrylate) precursor components, and is composed of the above components to form a mixed solution after It is prepared by photo-initiated free radical polymerization. In this system, acrylic acid and N-succinimidyl acrylate provide adhesion; the hydrophobic effect of methyl acrylate enhances its adhesion and anti-swelling ability in wet environments. In addition, chitosan oligosaccharide anti-adhesion modification treatment can also be performed on the hydrogel material to reduce postoperative adhesion. In short, the hydrogel is expected to be used as a repair material for dural damage in a wet environment, and has great clinical application. Value. |