| abstract |
The present invention relates to the application of phloretin in the preparation of PPK1 inhibitor, and through MIC value determination test, growth curve test, PPK1 enzyme activity inhibition test, bacterial polyP content determination test, hydrogen peroxide stimulation, heat stimulation and ampicillin retention Sexual experiments and mouse Acinetobacter baumannii infection model verified that phloretin can reduce the tolerance of Acinetobacter baumannii under hydrogen peroxide, heat stimulation and ampicillin stimulation by inhibiting PPK1 enzyme activity, and has good in vivo Anti-Acinetobacter baumannii infection effect. It provides a new approach and potential lead compounds for the prevention and treatment of Acinetobacter baumannii infection. |