http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-114732788-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_38de6562fb0feaae2c4563e3a130b1b4 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-4365 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P7-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-1652 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-1647 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-0095 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P9-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P7-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-38 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K9-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4365 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-14 |
| filingDate | 2022-04-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_66995493e4b0705963c67a3be9666486 |
| publicationDate | 2022-07-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-114732788-A |
| titleOfInvention | A kind of clopidogrel hydrogen sulfate solid preparation and preparation process thereof |
| abstract | The invention provides a clopidogrel hydrogen sulfate solid preparation and a preparation process thereof, belonging to the field of pharmaceutical preparations. The solid preparation of clopidogrel hydrogen sulfate, by weight percentage, comprises 0.1-30% of clopidogrel, 20-50% of filler, 1-5% of solubilizer, 3-10% of binder, and lubricant and glidant 1‑10%, sweeteners 10‑35% and aromatic flavorings 0.5‑10%. In the implementation process, the present invention adopts polyoxyethylene (8) stearate as a solubilizer, which can significantly improve the dissolution of the drug in vitro, and adopts hydroxypropyl cellulose as a binder to enhance the stability of the solid preparation of clopidogrel hydrogen sulfate. In addition, the present invention avoids the direct contact of clopidogrel with light and damp heat by embedding clopidogrel, and adopts a fluidized bed one-step granulation process, which fundamentally avoids the production process of traditional clopidogrel hydrogen sulfate preparations. Degradation problems that are prone to occur, improve drug stability. |
| priorityDate | 2022-04-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 59.