http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-114729894-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_0710666fecc8c8b297b6a32c30291907 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-54373 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N21-553 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N21-64 |
| filingDate | 2020-12-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_66f1a6fdbda58c186c4394a3e367e1f9 |
| publicationDate | 2022-07-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-114729894-A |
| titleOfInvention | Methods for Determining Aggregates |
| abstract | The present disclosure provides methods for determining aggregates comprising one or more macromolecules in a first sample that may comprise aggregates of one or more macromolecules, comprising the steps of: (a) causing a first The sample is brought into contact with a sensing surface of an interaction analysis sensor, the sensing surface having immobilized thereon a ligand comprising a hydrophobic group, which, compared to the one or more unaggregated macromolecules, is a hydrophobic group capable of increasing binding interactions with aggregates of one or more macromolecules; (b) determining at least one parameter for said interaction of said first sample with said sensing surface; (c) performing at least one of steps (i) and (ii): (i) comparing said at least one parameter determined in step (b) with at least one parameter for aggregates that may comprise one or more macromolecules (ii) determining at least one parameter associated with one or more aggregates of the one or more macromolecules; and (d) determining The presence, fraction, concentration and/or amount of one or more macromolecules in aggregate form in said first sample. The present disclosure also relates to uses of the methods and interaction analysis sensors for the methods, as well as interaction analysis sensors and methods for determining the stability of macromolecules. |
| priorityDate | 2019-12-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 33.