| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_dd42d36166059785d4ae90f52bfb596a |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K48-0058
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-7088
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-67
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-11 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-11
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-62
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K48-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-70 |
| filingDate |
2020-06-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_61c3311180ce1a4ce9d244d8bedb3c51
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f423764c3dc6ca7de60e4dc35a31b5c2
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e0ff264ffc715fdf1abbb63c328ddfec |
| publicationDate |
2022-07-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
CN-114729353-A |
| titleOfInvention |
Expression of engineered tumor-selective proteins |
| abstract |
The present disclosure provides techniques for achieving tumor-selective translation. The use of two complementary pipelines to study the translational landscape of cancer versus normal cells described in this disclosure enables the identification of tumor-selective sequences that can be used to engineer synthetic DNA or mRNA constructs for cancer cell-specific protein expression motif. The present disclosure characterizes tumor-selective motifs and provides embodiments for the design of modular tumor-selective constructs that can be used to encode payloads of high therapeutic interest. |
| priorityDate |
2019-06-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |