| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_872dd7cd609eb2a937dcfd303d521798
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_82720f0fe09c6d788db8fde9be2350dc |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q2537-165 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G16B20-10
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-1034
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q1-68
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N5-0018 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N5-071 |
| filingDate |
2020-09-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_179a16db6b0137d3e90f4d22b46f7cb0
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f92451ea08f21df0825c6c8a5fa15763
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_35b44278c54960e0a3cf4b9eec9fb877
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8f1baceb3de20edeb11cb1d74a96d778 |
| publicationDate |
2022-07-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
CN-114729309-A |
| titleOfInvention |
Methods for predicting the production stability of clonal cell lines |
| abstract |
The present invention relates to a method for predicting the production stability and/or production instability of a clonal cell line, the method comprising the steps of: a) culturing two or more clonal cell lines in different cell cultures; b) pairing The cells in each cell culture are karyotyped; c) a genomic instability value is derived from the karyotype of step (b). The present invention also relates to methods of selecting cell lines expressing therapeutic proteins and methods of selecting high titer producing clonal cell lines for large-scale therapeutic protein production. |
| priorityDate |
2019-09-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |