| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_1b411d2e57299da3818a07a52c388de6 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-61
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C08B37-0072 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C08B37-08
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-61 |
| filingDate |
2022-03-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e7069bd990944affc13c5852fc73885f
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b51672a090ed90480df98b2bbb261fae
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2f0ea14560117bf297966a14b1560616
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d2a4e1cfe97c3a1d3cb03367ff72dc9f
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a3ab5bb3f0eca5363adeebd5c1d22499
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_30e7adc68b8f30c7be9f0acbeb6e0995
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ce0ebd9d259d0236afa7171548da0e76 |
| publicationDate |
2022-07-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
CN-114716581-A |
| titleOfInvention |
A kind of multiple modified hyaluronic acid derivative and its application |
| abstract |
The invention discloses a multi-modified hyaluronic acid derivative and an application thereof. Since the multi-modified hyaluronic acid derivative of the present invention has both an amino group and a sulfhydryl group, it can be flexibly and efficiently used for the preparation of a hyaluronic acid-drug conjugate. In preparation, the coupling of various drugs and hyaluronic acid can be realized simultaneously through sulfhydryl and amino groups, and at the same time, a (double) cross-linked hydrogel can be prepared with a sulfhydryl-reactive cross-linking agent and/or an amino-reactive cross-linking agent. The multi-modified hyaluronic acid derivatives of the present invention have positive prospects in medical applications such as targeted anti-tumor therapy. |
| priorityDate |
2022-03-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |