http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-114702481-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_65fbb8b3f6eb8bad017fec5791ff4779 |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07B2200-07 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y02P20-55 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12P17-162 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12P41-004 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12P17-165 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D405-04 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D405-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12P17-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12P41-00 |
| filingDate | 2022-04-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d2bfec9b312044da7a253afb9d6547a2 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_176536ffa87d5c1f719655052a4c4db7 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_190b2a6de331e439f7776ef1918a3aeb http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_976af3cc520cb09e6269bfa8b819d91d |
| publicationDate | 2022-07-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-114702481-A |
| titleOfInvention | A kind of new synthetic method of pseudouridine |
| abstract | The invention discloses a new method for synthesizing pseudouridine, comprising the following steps: step 1) using D-ribose as a reaction starting material, adding acetyl bromide dropwise in an organic solvent to obtain intermediate I; step 2) using D-ribose as a reaction starting material Uracil is the starting material for the reaction, use a strong Lewis base in an organic solvent to eliminate active hydrogen, and add (Boc)2O in batches to obtain the corresponding intermediate II; step 3) Compound I and compound II are in an organic solvent, using strong Lewis Under alkaline conditions, condensation reaction occurs to obtain intermediate III. Then use trifluoroacetic acid to remove the protective group to obtain intermediate IV, then add acetic anhydride, carry out chiral resolution by lipase to obtain compound V, and finally remove under alkaline conditions. Removing the protecting group gives the final product VI, the pseudouridine product. The invention adopts mild and safe chemical reagents and enzymatic chiral separation, so as to shorten the reaction steps and reduce the difficulty of the reaction, thereby realizing the bottleneck of green synthesis technology. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-114940676-A |
| priorityDate | 2022-04-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 96.